Our award-winning science
Our preclinical work discovered the cell subpopulations damaging the heart and mapped their spatial microenvironments. This spatial arrangement dictates disease trajectory and therapy response.
Katz AwardAmerican Heart AssociationInnovative Project AwardAmerican Heart Association
Top 15 ventureCure MEHA II
The scientific foundation
2025 / Original research · Circulation
A regulatory myofibroblast subpopulation offers a cell-specific route to understanding protective repair.
2024 / Original research · Circulation Research
Fibroblast Smad7 restrains fibrosis, matrix degradation, and macrophage activation under pressure overload.
2022 / Original research · JCI
An endogenous signaling brake limits excessive myofibroblast activation after myocardial infarction.
2021 / Original research · Matrix Biology
Proteolysis and mechanical forces reshape the cardiac extracellular matrix at different stages of repair.
2020 / Original research · AJP
Histopathology connects rupture in experimental infarction to the balance of inflammation and repair.
2024 / Original research · JMCC
Macrophages influence fibrotic remodeling through their secreted signals while retaining myeloid identity.
The wider perspective
2026 / Review · Frontiers
Spatial transcriptomics links cellular identity to location, revealing the organization of heart injury.
2022 / Review · Cells
A synthesis of the diverse fibroblast and myofibroblast states involved in cardiac repair.
2021 / Review · Cellular Signalling
How context and cell identity shape the fibrotic effects of Smad signaling.
These publications provide scientific context and do not establish clinical efficacy of the CorSilico platform.
A new future for the failing heart
